MNN10 / YDR245W Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

MNN10/YDR245W is a non-essential gene; null mutants are viable, slow-growing, and exhibit a variety of phenotypic changes that impact cellular functions and overall fitness including decreased anaerobic growth indicating impaired energy production under oxygen-limited conditions, increased biofilm formation which could affect cell adhesion and surface interactions, increased cell size and chitin deposition suggesting alterations in cell wall structure and growth regulation, decreased chronological lifespan and competitive fitness making them less viable in competitive environments, decreased desiccation resistance making them more vulnerable to dry conditions, abnormal morphology of the endoplasmic reticulum which may affect protein synthesis and transport, increased heat sensitivity and decreased resistance to freeze-thaw cycles indicating heightened vulnerability to temperature fluctuations, decreased resistance to hyperosmotic stress, increased resistance to killer toxins, abnormal morphology of lipid particles which may impact lipid metabolism, decreased metal resistance, abnormal septum formation, increased size of nucleolus, and abnormal vacuolar morphology which could affect cellular organization and storage. Overexpression of MNN10 leads to slow growth and abnormal nuclear morphology and cell cycle progression, indicating disruptions in cell division and nuclear organization.

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources