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Gene Ontology Term: guanyl-nucleotide exchange factor activity

GO ID
GO:0005085
Aspect
Molecular Function
Description
Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.
Synonyms
GDP-dissociation stimulator activity, GDS, GEF, GNRP, guanyl-nucleotide release factor activity, guanyl-nucleotide releasing factor, Rho guanine nucleotide exchange factor, RhoGEF, ARF guanyl-nucleotide exchange factor activity, Rab guanyl-nucleotide exchange factor activity, Rac guanyl-nucleotide exchange factor activity, Ral guanyl-nucleotide exchange factor activity, Ran guanyl-nucleotide exchange factor activity, Rap guanyl-nucleotide exchange factor activity, Ras guanyl-nucleotide exchange factor activity, Rho guanyl-nucleotide exchange factor activity, Sar guanyl-nucleotide exchange factor activity, cAMP-dependent guanyl-nucleotide exchange factor activity
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Manually Curated

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Gene/Complex Qualifier Gene Ontology Term Aspect Annotation Extension Evidence Method Source Assigned On Reference

High-throughput

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Gene/Complex Qualifier Gene Ontology Term Aspect Annotation Extension Evidence Method Source Assigned On Reference

Computational

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Gene/Complex Qualifier Gene Ontology Term Aspect Annotation Extension Evidence Method Source Assigned On Reference