transcription coregulator activity

Gene Ontology Term: transcription coregulator activity

GO ID: GO:0003712
Aspect: Molecular Function
Description: A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.
Synonyms: transcription cofactor activity, transcriptional co-regulator, transcriptional cofactor activity, RNA polymerase II transcription cofactor activity, RNA polymerase II transcriptional cofactor activity, transcription cofactor activity, transcription coreceptor activity, nuclear receptor coreceptor activity