Primary Literature
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- Beauvais V, et al. (2023) Tho2 is critical for the recruitment of Rrp6 to chromatin in response to perturbed mRNP biogenesis. RNA 30(1):89-98 PMID: 37914399
- Kern C, et al. (2023) Cross-linking mass spectrometric analysis of the endogenous TREX complex from <i>Saccharomyces cerevisiae</i>. RNA 29(12):1870-1880 PMID: 37699651
- Brown RE, et al. (2022) The RNA export and RNA decay complexes THO and TRAMP prevent transcription-replication conflicts, DNA breaks, and CAG repeat contractions. PLoS Biol 20(12):e3001940 PMID: 36574440
- Chen C, et al. (2021) Structural and functional insights into R-loop prevention and mRNA export by budding yeast THO-Sub2 complex. Sci Bull (Beijing) 66(23): 2347-2352. PMID: 36654119
- Schuller SK, et al. (2020) Structural insights into the nucleic acid remodeling mechanisms of the yeast THO-Sub2 complex. Elife 9 PMID: 33191913
- Ren Y, et al. (2017) Structural and biochemical analyses of the DEAD-box ATPase Sub2 in association with THO or Yra1. Elife 6 PMID: 28059701
- Zhang Y, et al. (2016) The Transcription Factor THO Promotes Transcription Initiation and Elongation by RNA Polymerase I. J Biol Chem 291(6):3010-8 PMID: 26663077
- Bonnet A, et al. (2015) Nuclear pore components affect distinct stages of intron-containing gene expression. Nucleic Acids Res 43(8):4249-61 PMID: 25845599
- Bretes H, et al. (2014) Sumoylation of the THO complex regulates the biogenesis of a subset of mRNPs. Nucleic Acids Res 42(8):5043-58 PMID: 24500206
- Chan YA, et al. (2014) Genome-wide profiling of yeast DNA:RNA hybrid prone sites with DRIP-chip. PLoS Genet 10(4):e1004288 PMID: 24743342
- Poulsen JB, et al. (2014) Structural characterization of the Saccharomyces cerevisiae THO complex by small-angle X-ray scattering. PLoS One 9(7):e103470 PMID: 25062267
- Yu TY, et al. (2014) Telomeric transcripts stimulate telomere recombination to suppress senescence in cells lacking telomerase. Proc Natl Acad Sci U S A 111(9):3377-82 PMID: 24550456
- Mouaikel J, et al. (2013) High-frequency promoter firing links THO complex function to heavy chromatin formation. Cell Rep 5(4):1082-94 PMID: 24210826
- Saguez C, et al. (2013) Mutational analysis of the yeast RNA helicase Sub2p reveals conserved domains required for growth, mRNA export, and genomic stability. RNA 19(10):1363-71 PMID: 23962665
- Gewartowski K, et al. (2012) The yeast THO complex forms a 5-subunit assembly that directly interacts with active chromatin. Bioarchitecture 2(4):134-7 PMID: 22964977
- Peña A, et al. (2012) Architecture and nucleic acids recognition mechanism of the THO complex, an mRNP assembly factor. EMBO J 31(6):1605-16 PMID: 22314234
- Yu TY, et al. (2012) Depleting components of the THO complex causes increased telomere length by reducing the expression of the telomere-associated protein Rif1p. PLoS One 7(3):e33498 PMID: 22448247
- Jimeno S, et al. (2011) New suppressors of THO mutations identify Thp3 (Ypr045c)-Csn12 as a protein complex involved in transcription elongation. Mol Cell Biol 31(4):674-85 PMID: 21149575
- Kim N and Jinks-Robertson S (2011) Guanine repeat-containing sequences confer transcription-dependent instability in an orientation-specific manner in yeast. DNA Repair (Amst) 10(9):953-60 PMID: 21813340
- Dufu K, et al. (2010) ATP is required for interactions between UAP56 and two conserved mRNA export proteins, Aly and CIP29, to assemble the TREX complex. Genes Dev 24(18):2043-53 PMID: 20844015
- Gómez-González B, et al. (2009) The S-phase checkpoint is required to respond to R-loops accumulated in THO mutants. Mol Cell Biol 29(19):5203-13 PMID: 19651896
- Hobeika M, et al. (2009) Structural requirements for the ubiquitin-associated domain of the mRNA export factor Mex67 to bind its specific targets, the transcription elongation THO complex component Hpr1 and nucleoporin FXFG repeats. J Biol Chem 284(26):17575-83 PMID: 19401465
- Assenholt J, et al. (2008) Exonucleolysis is required for nuclear mRNA quality control in yeast THO mutants. RNA 14(11):2305-13 PMID: 18824516
- Jimeno S, et al. (2008) A reduction in RNA polymerase II initiation rate suppresses hyper-recombination and transcription-elongation impairment of THO mutants. Mol Genet Genomics 280(4):327-36 PMID: 18682986
- Milligan L, et al. (2008) A yeast exosome cofactor, Mpp6, functions in RNA surveillance and in the degradation of noncoding RNA transcripts. Mol Cell Biol 28(17):5446-57 PMID: 18591258
- Rondon AG and Proudfoot NJ (2008) Nuclear roadblocks for mRNA export. Cell 135(2):207-8 PMID: 18957194
- Rougemaille M, et al. (2008) THO/Sub2p functions to coordinate 3'-end processing with gene-nuclear pore association. Cell 135(2):308-21 PMID: 18957205
- Saguez C, et al. (2008) Nuclear mRNA surveillance in THO/sub2 mutants is triggered by inefficient polyadenylation. Mol Cell 31(1):91-103 PMID: 18614048
- Hobeika M, et al. (2007) Coordination of Hpr1 and ubiquitin binding by the UBA domain of the mRNA export factor Mex67. Mol Biol Cell 18(7):2561-8 PMID: 17475778
- Rollenhagen C, et al. (2007) Following temperature stress, export of heat shock mRNA occurs efficiently in cells with mutations in genes normally important for mRNA export. Eukaryot Cell 6(3):505-13 PMID: 17259545
- Tous C and Aguilera A (2007) Impairment of transcription elongation by R-loops in vitro. Biochem Biophys Res Commun 360(2):428-32 PMID: 17603014
- Huertas P, et al. (2006) An hpr1 point mutation that impairs transcription and mRNP biogenesis without increasing recombination. Mol Cell Biol 26(20):7451-65 PMID: 16908536
- Jimeno S, et al. (2006) Tho1, a novel hnRNP, and Sub2 provide alternative pathways for mRNP biogenesis in yeast THO mutants. Mol Cell Biol 26(12):4387-98 PMID: 16738307
- Voynov V, et al. (2006) Genes with internal repeats require the THO complex for transcription. Proc Natl Acad Sci U S A 103(39):14423-8 PMID: 16983072
- Gwizdek C, et al. (2005) The mRNA nuclear export factor Hpr1 is regulated by Rsp5-mediated ubiquitylation. J Biol Chem 280(14):13401-5 PMID: 15713680
- Mason PB and Struhl K (2005) Distinction and relationship between elongation rate and processivity of RNA polymerase II in vivo. Mol Cell 17(6):831-40 PMID: 15780939
- Olesen JR, et al. (2005) A link between transcription and mRNP quality in Saccharomyces cerevisiae. RNA Biol 2(2):45-8 PMID: 17132939
- Häcker S and Krebber H (2004) Differential export requirements for shuttling serine/arginine-type mRNA-binding proteins. J Biol Chem 279(7):5049-52 PMID: 14676199
- Kim M, et al. (2004) Transitions in RNA polymerase II elongation complexes at the 3' ends of genes. EMBO J 23(2):354-64 PMID: 14739930
- Rondón AG, et al. (2003) Molecular evidence for a positive role of Spt4 in transcription elongation. EMBO J 22(3):612-20 PMID: 12554661
- Rondón AG, et al. (2003) Molecular evidence that the eukaryotic THO/TREX complex is required for efficient transcription elongation. J Biol Chem 278(40):39037-43 PMID: 12871933
- González-Barrera S, et al. (2002) Defective nucleotide excision repair in yeast hpr1 and tho2 mutants. Nucleic Acids Res 30(10):2193-201 PMID: 12000839
- Jimeno S, et al. (2002) The yeast THO complex and mRNA export factors link RNA metabolism with transcription and genome instability. EMBO J 21(13):3526-35 PMID: 12093753
- Libri D, et al. (2002) Interactions between mRNA export commitment, 3'-end quality control, and nuclear degradation. Mol Cell Biol 22(23):8254-66 PMID: 12417728
- Strässer K, et al. (2002) TREX is a conserved complex coupling transcription with messenger RNA export. Nature 417(6886):304-8 PMID: 11979277
- Chávez S, et al. (2001) Hpr1 is preferentially required for transcription of either long or G+C-rich DNA sequences in Saccharomyces cerevisiae. Mol Cell Biol 21(20):7054-64 PMID: 11564888
- Chávez S, et al. (2000) A protein complex containing Tho2, Hpr1, Mft1 and a novel protein, Thp2, connects transcription elongation with mitotic recombination in Saccharomyces cerevisiae. EMBO J 19(21):5824-34 PMID: 11060033