Gene Ontology Help

ERF1-ERF3 translation release factor complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.


Summary
Required for the termination of protein synthesis which occurs when one of three stop codons (UAA, UAG or UGA) enters the ribosomal A site. eRF1 stimulates GTP binding to eRF3, inducing the GTPase activity of eRF3 that couples codon recognition and eRF1 peptidyl-tRNA hydrolysis to ensure rapid and efficient peptide release from the ribosome.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

GTPase activity, hydrolase activity, translation factor activity, RNA binding, biological process, cytoplasm