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Gene Ontology Help

Glucosidase II complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

Summary
Glycoprotein-processing enzyme that successively cleaves the innermost two alpha1,3-linked glucose residues from N-linked oligosaccharides in the endoplasmic reticulum during glycoprotein biogenesis. The enzyme has dual activity, cleaving two alpha1,3-linked glucose residues in succession from Glc2Man9GlcNAc2 (G2M9) to Glc1Man9GlcNAc2 (G1M9) (cleavage-1), and then to Man9GlcNAc2 (M9) (cleavage-2). G1M9 plays a key role in glycoprotein quality control in the ER, because it is a primary ligand of the lectin chaperones calnexin (CNX) and calreticulin (CRT). Therefore, the cleavage-2 activity provides an exit for correctly folded glycoproteins from the CNX/CRT cycle, while the cleavage-1 activity provides an entry for immature glycoproteins into the cycle.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

hydrolase activity, hydrolase activity, acting on glycosyl bonds, biosynthetic process, carbohydrate metabolic process

Biological Process

Manually curated GO annotations reflect our best understanding of the basic biological process for this protein complex. Manually curated annotations are assigned by curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all manually curated GO annotations for accuracy and completeness.

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Qualifier Gene Ontology Term Annotation Extension Evidence Source Assigned On Reference

Molecular Function

Manually curated GO annotations reflect our best understanding of the basic molecular function for this protein complex. Manually curated annotations are assigned by curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all manually curated GO annotations for accuracy and completeness.

Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

Qualifier Gene Ontology Term Annotation Extension Evidence Source Assigned On Reference

Shared Annotations

This diagram displays Gene Ontology terms (green) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). Note: No diagram is shown ("No shared annotations") if there are less than 2 shared GO annotations between this complex and any other complexes.

No shared annotations