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Complex: Vacuolar transporter chaperone complex, VTC3 variant

Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background.

Curated by
IntAct
ComplexAc
CPX-784
Systematic Name
VTC1:VTC3:VTC4
SGD ID
SGD:S000217910
Aliases
VTC
Description
Polyphosphate (polyP) polymerase that synthesizes polyP from ATP and translocates polyP across the vacuolar membrane to maintain an intracellular phosphate (Pi) homeostasis. Integral membrane complex enriched at the vacuolar membrane, but also localizes to other cellular compartments. VTC proteins have been implicated in several membrane-related processes, such as sorting of H+-translocating ATPases, endocytosis, ER-Golgi trafficking, vacuole fusion, and the microautophagic scission of vesicles into the vacuolar lumen. May bind calmodulin during some, or all, of these processes. This VTC3 variant is located mostly in the vacuole. VTC5 (P38966) can associate with the VTC complex and may act as an optional regulatory subunit.

Complex Diagram

This diagram displays the protein subunits (blue) of the complex and how they interact with each other. Interactions with other relevant participants such as small molecules (purple), sub-complexes (yellow), and other subunits (red) are also shown. If a participant appears in the diagram with no lines connected to it, then its specific interactions with other participants are currently unknown.

PDB Structure

When available from the Protein Data Bank (PDB), the physical structure of the macromolecular complex is displayed. Click on the image or link for further information about the physical structure.

7YTJ 7YTJ 8I6V 8I6V

Subunits

This table lists all participants of the complex (proteins, small molecules, nucleic acids, etc.) and their respective stoichiometry. A brief description is also provided for each participant in the table.

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Subunit Description Stoichiometry

Gene Ontology

Gene Ontology (GO) terms that describe the function of a complex, the biological process in which it participates, or its cellular location. Click on a term for its definition and other objects annotated to that term.

Shared Annotations

This diagram displays Gene Ontology terms (green) and subunits (blue) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). The shared GO terms or subunits can be visualized separately using the radio button at the bottom of the graph. Note: No diagram is shown ("No shared annotations") if there are less than 2 shared annotations (either GO terms or subunits of other complexes) between this complex and any other complexes.

References

List of references used specifically to curate the information on this page.

External Identifiers

EMDB: EMD-34090 | EMDB: EMD-35208

Resources

IntAct | ModelArchive | PDB:7YTJ | PDB:8I6V