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Complex: Snf1 protein kinase complex variant SIP2

Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background.

Curated by
IntAct
ComplexAc
CPX-2800
Systematic Name
SIP2:SNF1:SNF4
SGD ID
SGD:S000218121
Aliases
AMP-activated protein kinase complex ; AMPK ; Snf1 serine/threonine protein kinase complex
Description
Energy sensor protein kinase complex, activated by glucose depletion. Regulates cellular energy metabolism by activating energy-producing pathways and inhibiting energy-consuming processes via derepression of glucose-repressed genes. Required for the diauxic shift, in which genes required for mitochondrial oxidative metabolism (normally repressed by glucose) are switched on; growth then resumes at a lower rate. Role in filamentous invasive growth, on glucose depletion, in haploid cells. The activity of this complex is modulated by reversible phosphorylation of SNF1 Thr-210 which increases in response to glucose starvation and correlates with large increases in cellular ADP-to-ATP and AMP-to-ATP ratios. Binding of ADP, but not AMP, to the complex protects against dephosphorylation of Thr-210, suggesting that ADP, rather than AMP, may be the critical activating signal. When glucose levels are high, the complex is cytoplasmic. Upon glucose depletion, SIP2-containing SNF1 remain in the cytosol.

Complex Diagram

This diagram displays the protein subunits (blue) of the complex and how they interact with each other. Interactions with other relevant participants such as small molecules (purple), sub-complexes (yellow), and other subunits (red) are also shown. If a participant appears in the diagram with no lines connected to it, then its specific interactions with other participants are currently unknown.

PDB Structure

When available from the Protein Data Bank (PDB), the physical structure of the macromolecular complex is displayed. Click on the image or link for further information about the physical structure.

2QLV 2QLV 3T4N 3T4N 3TDH 3TDH 3TE5 3TE5

Subunits

This table lists all participants of the complex (proteins, small molecules, nucleic acids, etc.) and their respective stoichiometry. A brief description is also provided for each participant in the table.

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Subunit Description Stoichiometry

Gene Ontology

Gene Ontology (GO) terms that describe the function of a complex, the biological process in which it participates, or its cellular location. Click on a term for its definition and other objects annotated to that term.

Shared Annotations

This diagram displays Gene Ontology terms (green) and subunits (blue) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). The shared GO terms or subunits can be visualized separately using the radio button at the bottom of the graph. Note: No diagram is shown ("No shared annotations") if there are less than 2 shared annotations (either GO terms or subunits of other complexes) between this complex and any other complexes.

References

List of references used specifically to curate the information on this page.

External Identifiers

IntEnz: 2.7.11.1

Resources

IntAct | ModelArchive | PDB:2QLV | PDB:3T4N | PDB:3TDH | PDB:3TE5