Complex: Ire1 serine/threonine-protein kinase/endoribonuclease complex
Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background.
- Curated by
- IntAct
- ComplexAc
- CPX-2147
- Systematic Name
- IRE1 dimer
- SGD ID
- SGD:S000217939
- Aliases
- Ire1 oligomer ; Serine/threonine-protein kinase/endoribonuclease IRE1
- Description
- Endoplasmic reticulum localized, type-I transmembrane homodimer which forms in response to the accumulation of unfolded protein in the ER and evokes the unfolded protein response (UPR) by splicing the mRNA encoding master transcriptional regulator of the UPR, HAC1 (P41546). IRE1 cleaves a single phosphodiester bond in each of two RNA hairpins (with non-specific base paired stems and loops of consensus sequence CNCNNGN, where N is any base) to remove an intervening intron from the target transcript. IRE1 auto-activates via transphosphorylation following binding of unfolded proteins to its N-termini.
Complex Diagram
This diagram displays the protein subunits (blue) of the complex and how they interact with each other. Interactions with other relevant participants such as small molecules (purple), sub-complexes (yellow), and other subunits (red) are also shown. If a participant appears in the diagram with no lines connected to it, then its specific interactions with other participants are currently unknown.
Subunits
This table lists all participants of the complex (proteins, small molecules, nucleic acids, etc.) and their respective stoichiometry. A brief description is also provided for each participant in the table.
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| Subunit | Description | Stoichiometry |
|---|
Gene Ontology
Gene Ontology (GO) terms that describe the function of a complex, the biological process in which it participates, or its cellular location. Click on a term for its definition and other objects annotated to that term.
- Molecular Function
-
- enables ATP binding (IDA)
- enables RNA endonuclease activity (IDA)
- enables RNA endonuclease activity (IDA)
- enables protein serine/threonine kinase activity (IDA)
- enables unfolded protein binding (IDA)
- Biological Process
-
- involved in IRE1-mediated unfolded protein response (IDA)
- involved in mitochondrial unfolded protein response (IMP)
- Cellular Component
-
- located in endoplasmic reticulum membrane (BSR)
- is active in mitochondrial intermembrane space (IDA)
Shared Annotations
This diagram displays Gene Ontology terms (green) and subunits (blue) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). The shared GO terms or subunits can be visualized separately using the radio button at the bottom of the graph. Note: No diagram is shown ("No shared annotations") if there are less than 2 shared annotations (either GO terms or subunits of other complexes) between this complex and any other complexes.
References
List of references used specifically to curate the information on this page.
- Korennykh AV, et al. (2009) The unfolded protein response signals through high-order assembly of Ire1. Nature 457(7230):687-93 PMID: 19079236
Resources
IntAct | ModelArchive | PDB:2RIO | PDB:3FBV | PDB:3LJ0 | PDB:3LJ1 | PDB:3LJ2 | PDB:3SDJ | PDB:3SDM ... Show all Show fewer