Complex: General transcription factor TFIIH complex
Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background.
- Curated by
- IntAct
- ComplexAc
- CPX-1659
- Systematic Name
- CCL1:KIN28:SSL1:RAD3:RAD25:TFB1:TFB2:TFB3:TFB4:TFB5
- SGD ID
- SGD:S000218045
- Aliases
- Kin28p complex ; TFIIK complex
- Description
- A general transcription factor which plays a central role in both RNA polymerase II transcription and DNA repair. Component of the Pol II preinitiation complex. The TFIIH subunit XPB is an ATP-dependent translocase that promotes DNA strand separation and promoter escape. During the transition from initiation to promoter clearance, the kinase subunit Kin28 phosphorylates Ser-5 and Ser-7 within the Pol II carboxyl terminal domain (CTD). This phosphorylation initiates a cascade of phosphorylation/dephosphorylation events on the CTD that correlates with dissociation of Pol II from the initiation machinery and its association with elongation and mRNA processing factors. This is the only general transcription factor with enzyme activity. During nucleotide excision repair, TFIIH is required for opening DNA around lesions that disrupt base pairing to permit excision of the damaged DNA and its replacement by a new DNA fragment.
Complex Diagram
This diagram displays the protein subunits (blue) of the complex and how they interact with each other. Interactions with other relevant participants such as small molecules (purple), sub-complexes (yellow), and other subunits (red) are also shown. If a participant appears in the diagram with no lines connected to it, then its specific interactions with other participants are currently unknown.
Subunits
This table lists all participants of the complex (proteins, small molecules, nucleic acids, etc.) and their respective stoichiometry. A brief description is also provided for each participant in the table.
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| Subunit | Description | Stoichiometry |
|---|
Gene Ontology
Gene Ontology (GO) terms that describe the function of a complex, the biological process in which it participates, or its cellular location. Click on a term for its definition and other objects annotated to that term.
- Molecular Function
-
- enables RNA polymerase II CTD heptapeptide repeat kinase activity (IDA)
- Biological Process
-
- involved in nucleotide-excision repair (IDA)
- involved in phosphorylation of RNA polymerase II C-terminal domain (IDA)
- involved in transcription initiation at RNA polymerase II promoter (IDA)
Shared Annotations
This diagram displays Gene Ontology terms (green) and subunits (blue) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). The shared GO terms or subunits can be visualized separately using the radio button at the bottom of the graph. Note: No diagram is shown ("No shared annotations") if there are less than 2 shared annotations (either GO terms or subunits of other complexes) between this complex and any other complexes.
References
List of references used specifically to curate the information on this page.
- Compe E and Egly JM (2012) TFIIH: when transcription met DNA repair. Nat Rev Mol Cell Biol 13(6):343-54 PMID: 22572993
Resources
IntAct | ModelArchive | PDB:3DGP | PDB:3DOM ... Show all Show fewer