Alcoholic fermentation is a complex biochemical process that profoundly impacts wine quality. Generally, most metabolomics studies focus on controlled laboratory-scale fermentations, and industrial conditions are very rarely investigated. This study addresses this gap by elucidating the metabolomic fingerprint changes of Muscat of Alexandria grape must during industrial-scale alcoholic fermentation, by applying a Mass Spectrometry-based untargeted metabolomics workflow. The results revealed that small peptides exhibited analogous trends to amino acids, since the concentration of some peptides decreased rapidly at the early stages of the fermentation, explaining the increase of the not preferred by yeasts proline, while other peptides accumulated towards fermentation's end. Additionally, terpenes and phenolics glycosidic bonds underwent hydrolysis, and nucleic acid building blocks were released into the must during fermentation. These metabolomic transformations may shape wine's longevity, identity and sensory profile, and therefore the outputs of this work are important in wine science and winemaking.
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| Evidence ID | Analyze ID | Gene/Complex | Systematic Name/Complex Accession | Qualifier | Gene Ontology Term ID | Gene Ontology Term | Aspect | Annotation Extension | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Phenotype | Experiment Type | Experiment Type Category | Mutant Information | Strain Background | Chemical | Details | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Disease Ontology Term | Disease Ontology Term ID | Qualifier | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Regulator | Regulator Systematic Name | Target | Target Systematic Name | Direction | Regulation of | Happens During | Regulator Type | Direction | Regulation Of | Happens During | Method | Evidence | Strain Background | Reference |
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| Site | Modification | Modifier | Source | Reference |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Allele | Assay | Annotation | Action | Phenotype | SGA score | P-value | Source | Reference | Note |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Assay | Annotation | Action | Modification | Source | Reference | Note |
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| Complement ID | Locus ID | Gene | Species | Gene ID | Strain background | Direction | Details | Source | Reference |
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| Evidence ID | Analyze ID | Dataset | Description | Keywords | Number of Conditions | Reference |
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