Chloroplasts require iron for photosynthesis; however, the transport mechanisms remain poorly understood. This study identifies Arabidopsis Fe-deficiency-induced chlorosis 1 (FIC1), localized in the chloroplast inner membrane, as essential for iron redistribution from developed to newly developing leaves under continuous light (CL) conditions. CL induces FIC1 expression in newly developing leaves. fic1 displays chlorosis in newly developing leaves under iron deficiency or CL, with reduced levels of iron and photosynthetic complexes, along with an overaccumulation of reactive oxygen species (ROS). Iron supplementation alleviates these phenotypes. FIC1 functionally complements iron transport defects in fet3fet4 yeast and enhances iron uptake in Xenopus oocytes. Expressing PIC1 (PERMEASE IN CHLOROPLAST 1) under FIC1 promoter rescues both the deficits in iron/chlorophyll content and ROS accumulation in fic1. Furthermore, FIC1 modulates iron homeostasis-related gene expression under CL. These findings establish FIC1 as a chloroplast iron importer that is essential for prioritizing iron allocation to young tissues during prolonged light exposure.
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Evidence ID | Analyze ID | Gene/Complex | Systematic Name/Complex Accession | Qualifier | Gene Ontology Term ID | Gene Ontology Term | Aspect | Annotation Extension | Evidence | Method | Source | Assigned On | Reference |
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Evidence ID | Analyze ID | Gene | Gene Systematic Name | Phenotype | Experiment Type | Experiment Type Category | Mutant Information | Strain Background | Chemical | Details | Reference |
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Evidence ID | Analyze ID | Gene | Gene Systematic Name | Disease Ontology Term | Disease Ontology Term ID | Qualifier | Evidence | Method | Source | Assigned On | Reference |
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Evidence ID | Analyze ID | Regulator | Regulator Systematic Name | Target | Target Systematic Name | Direction | Regulation of | Happens During | Regulator Type | Direction | Regulation Of | Happens During | Method | Evidence | Strain Background | Reference |
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Site | Modification | Modifier | Source | Reference |
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Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Allele | Assay | Annotation | Action | Phenotype | SGA score | P-value | Source | Reference | Note |
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Complement ID | Locus ID | Gene | Species | Gene ID | Strain background | Direction | Details | Source | Reference |
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Evidence ID | Analyze ID | Dataset | Description | Keywords | Number of Conditions | Reference |
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