The utilization of microbial cell factories for industrial chemical production from renewable feedstocks provides a promising strategy for achieving sustainable biomanufacturing. However, cellular morphology significantly affects the efficacy of microbial cells as production platforms. Morphology engineering aims to "harnessing production through morphology" by reprogramming cellular architecture across multiple scales, thereby unlocking cellular potential to develop high-performance microbial cell factories. This review summarizes the mechanisms for maintaining cell morphology in rod-shaped bacteria and yeasts. Subsequently, we analyze current three main applications of morphology engineering in optimizing microbial cell factories. By increasing the length and width of short rod-shaped bacteria, the cell volume is increased to promote the accumulation of intracellular products. By reducing the size of the mycelial globules of actinomycetes, nutrient absorption is promoted to increase the yield of natural products. By increasing the area of yeast organelles and cell membranes, the yield of terpene products is enhanced. Furthermore, the current limitations of morphology engineering and its future development directions are proposed. This provides theoretical frameworks and technical references for promoting the development of morphology engineering.
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| Evidence ID | Analyze ID | Gene/Complex | Systematic Name/Complex Accession | Qualifier | Gene Ontology Term ID | Gene Ontology Term | Aspect | Annotation Extension | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Phenotype | Experiment Type | Experiment Type Category | Mutant Information | Strain Background | Chemical | Details | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Disease Ontology Term | Disease Ontology Term ID | Qualifier | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Regulator | Regulator Systematic Name | Target | Target Systematic Name | Direction | Regulation of | Happens During | Regulator Type | Direction | Regulation Of | Happens During | Method | Evidence | Strain Background | Reference |
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| Site | Modification | Modifier | Source | Reference |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Allele | Assay | Annotation | Action | Phenotype | SGA score | P-value | Source | Reference | Note |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Assay | Annotation | Action | Modification | Source | Reference | Note |
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| Complement ID | Locus ID | Gene | Species | Gene ID | Strain background | Direction | Details | Source | Reference |
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| Evidence ID | Analyze ID | Dataset | Description | Keywords | Number of Conditions | Reference |
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