Reference: Karpel JE (2024) Caenorhabditis elegansddx-15 helicase fails to complement loss of Prp43p in Saccharomyces cerevisiae. MicroPubl Biol 2024.

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Abstract


Helicase proteins have important roles in many aspects of RNA metabolism in the cell. The function of these highly conserved proteins is commonly preserved between organisms, yet in a few cases these homologues are found to have slightly different biochemical functions. Prp43 is a protein with varied roles in yeast, but here we show that the C. elegans homologue of this protein is unable to rescue the loss of Prp43p. By employing a transcriptional repression experiment, the expression of DDX-15 protein in yeast is not enough to complement the loss of Prp43p, which is a yeast essential protein.

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Karpel JE
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