Reference: Kasselimi E, et al. (2022) Ribosomal DNA and the nucleolus at the heart of aging. Trends Biochem Sci 47(4):328-341

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Abstract


The rRNA genes [ribosomal DNA (rDNA)] are organized in a prominent nuclear compartment, the nucleolus. It is now well established that the nucleolus functions beyond ribosome biosynthesis, regulating several physiological cellular responses. The nucleoli constitute dynamic genomic/nuclear hubs and demonstrate unique inherent characteristics, rendering them ideal to sense, signal, and respond to various intrinsic and environmental insults. Here, we discuss emerging findings supporting direct links between rDNA/nucleolar instability and cellular senescence/organismal aging from yeast to mammals. Moreover, we highlight evidence that nucleolar functionality and rDNA architecture impact on meiotic/transgenerational rejuvenation, thus revealing causality underlying connections between rDNA/nucleolar instability and aging.

Reference Type
Journal Article | Research Support, Non-U.S. Gov't | Review
Authors
Kasselimi E, Pefani DE, Taraviras S, Lygerou Z
Review For
SIR4 | SIR2 | SGS1 | FOB1 | WHI5 | SAGA complex