Sphingolipids and their intermediates play multiple roles in biological processes. The sphingoid long-chain base component of sphingolipids has emerged as a participant in the regulation of plant biotic and abiotic stress responses. The phytohormone abscisic acid (ABA) regulates many stress responses in plants for environmental adaptation. However, the relationship between the sphingoid bases and ABA is undetermined. In this study, mhp1-1 (the yeast Mpo1 homolog in plants) was isolated through a sodium chloride (NaCl)-sensitivity screen of Arabidopsis transfer DNA (T-DNA) insertion mutants. mhp1-1 was hypersensitivity to salt/osmotic stress and ABA. MHP1 encodes a protein with a domain of unknown function 962 (DUF962). Endoplasmic reticulum-localized MHP1 was found to interact with ABI1. MHP1, a homolog of yeast dioxygenase Mpo1, rescued the growth arrest of mpo1Δ cells caused by ER stress, suggesting functional homology of MHP1 to Mpo1. Overall, MHP1 plays important roles in response to ABA.
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| Evidence ID | Analyze ID | Gene/Complex | Systematic Name/Complex Accession | Qualifier | Gene Ontology Term ID | Gene Ontology Term | Aspect | Annotation Extension | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Phenotype | Experiment Type | Experiment Type Category | Mutant Information | Strain Background | Chemical | Details | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Disease Ontology Term | Disease Ontology Term ID | Qualifier | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Regulator | Regulator Systematic Name | Target | Target Systematic Name | Direction | Regulation of | Happens During | Regulator Type | Direction | Regulation Of | Happens During | Method | Evidence | Strain Background | Reference |
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| Site | Modification | Modifier | Source | Reference |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Allele | Assay | Annotation | Action | Phenotype | SGA score | P-value | Source | Reference | Note |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Assay | Annotation | Action | Modification | Source | Reference | Note |
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| Complement ID | Locus ID | Gene | Species | Gene ID | Strain background | Direction | Details | Source | Reference |
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| Evidence ID | Analyze ID | Dataset | Description | Keywords | Number of Conditions | Reference |
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| Evidence ID | Analyze ID | File | Description |
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