Reference: Ayra-Plasencia J and Machín F (2019) Yeast cells can partially revert chromosome segregation to repair late DNA double-strand breaks through homologous recombination. Mol Cell Oncol 6(5):e1648027

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Abstract


DNA repair in late mitosis sets paradoxical scenarios. Cyclin-dependent kinase (CDK) activity is high, which favors homologous recombination (HR), despite a sister chromatid is not physically close to recombine with. We have found that DNA double-strand breaks partially revert chromosome segregation to find an intact template and repair through HR.

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Journal Article
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Ayra-Plasencia J, Machín F
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