Reference: Yin JW and Wang G (2014) The Mediator complex: a master coordinator of transcription and cell lineage development. Development 141(5): 977-87.

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Abstract


Mediator is a multiprotein complex that is required for gene transcription by RNA polymerase II. Multiple subunits of the complex show specificity in relaying information from signals and transcription factors to the RNA polymerase II machinery, thus enabling control of the expression of specific genes. Recent studies have also provided novel mechanistic insights into the roles of Mediator in epigenetic regulation, transcriptional elongation, termination, mRNA processing, noncoding RNA activation and super enhancer formation. Based on these specific roles in gene regulation, Mediator has emerged as a master coordinator of development and cell lineage determination. Here, we describe the most recent advances in understanding the mechanisms of Mediator function, with an emphasis on its role during development and disease.

Reference Type
Journal Article | Research Support, Non-U.S. Gov't | Review
Authors
Yin JW, Wang G
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Gene Ontology Annotations


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Gene Qualifier Gene Ontology Term Aspect Annotation Extension Evidence Method Source Assigned On Reference

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Gene Phenotype Experiment Type Mutant Information Strain Background Chemical Details Reference

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Gene Disease Ontology Term Qualifier Evidence Method Source Assigned On Reference

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Post-translational Modifications


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Site Modification Modifier Reference

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Interactor Interactor Type Assay Annotation Action Modification Phenotype Source Reference