Reference: Rodriguez-Furlán C, et al. (2018) Chemical Genomics Translatability from Unicellular to Multicellular Models. Methods Mol Biol 1795:189-201

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Abstract


Chemical genomics has proven to be a useful and successful approach to study complex systems where conventional genetics fails to render feasible results. High-throughput phenotype screenings in model organisms have identified a large collection of powerful and selective bioactive chemicals. Nevertheless, applying chemical high-throughput screening to crops still represents a big challenge for researchers. Fortunately, a circumvent approach could be taken by means of translational research. In this case, searching bioactive chemicals in a much handy model organism would be the starting point for discovering compounds with activity in relevant plants for improving a desirable trait. In this chapter, we describe strategies that have been proven to successfully translate chemical biology and genetics from unicellular yeast to Arabidopsis thaliana and finally to crops.

Reference Type
Journal Article | Research Support, Non-U.S. Gov't
Authors
Rodriguez-Furlán C, Rubilar-Hernández C, Norambuena L
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