AboutBlogDownloadExploreHelpGet Data

Reference: Hantsche M and Cramer P (2017) Conserved RNA polymerase II initiation complex structure. Curr Opin Struct Biol 47:17-22

Reference Help

Abstract

Recent cryo-electron microscopic studies have arrived at atomic models of the core transcription initiation complex comprising RNA polymerase (Pol) II and the basal transcription factors TBP, TFIIA, TFIIB, TFIIE, and TFIIF. A detailed comparison of two independently derived yeast and human core initiation complex structures reveals that they are virtually identical, demonstrating the conservation of the basic transcription machinery amongst eukaryotes. The additional factors TFIID, TFIIH, and Mediator have been located on the periphery of the core initiation complex, providing the topology of the entire initiation assembly, which comprises approximately 70 polypeptides with a molecular weight of ∼4 Megadalton.

Reference Type
Journal Article | Review
Authors
Hantsche M, Cramer P
Primary Lit For
General transcription factor TFIIF complex | Transcription factor TFIIA complex | General transcription factor complex TFIID | General transcription factor complex TFIIE | General transcription factor TFIIH complex
Review For
TFA2 | SSL2 | RPB9 | RPB7 | RPB4 | SRB7 | TFB1 | RPC10 | MED6 | TAF2 | TAF6 | ... Show all