Kozjak-Pavlovic V (2017)

Abstract

Mitochondria are organelles of endosymbiotic origin, surrounded by two membranes. The inner membrane forms invaginations called cristae that enhance its surface and are important for mitochondrial function. A recently described mitochondrial contact site and cristae organizing system (MICOS) in the inner mitochondrial membrane is crucial for the formation and maintenance of cristae structure. The MICOS complex in human mitochondria exhibits specificities and greater complexity in comparison to the yeast system. Many subunits of this complex have been previously described, but several others and their function remain to be explored. This review will summarize our present knowledge about the human MICOS complex and its constituents, while discussing the future research perspectives in this exciting and important field.

PMID: 27245231
DOI full text
PubMed
PubTator

Download Citation (.nbib)

Reference Type: Journal Article | Review
Authors: Kozjak-Pavlovic V
Primary Lit For: MICOS mitochondrial contact site and cristae organizing system complex
Additional Lit For
Review For: MIC12 | SAM35 | MIC19 | SAM50 | SAM37 | MIC27 | MIC26 | MIC60 | MIC10

Increase the total number of rows displayed on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; to filter the table by a specific experiment type, type a keyword into the Filter box (for example, “microarray”); download this table as a .txt file using the Download button or click Analyze to further view and analyze the list of target genes using GO Term Finder, GO Slim Mapper, or SPELL.

Interaction Annotations