Reference: Singh V, et al. (2015)
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Abstract
The Nrd1-Nab3-Sen1 (NNS) complex terminates transcription of non-coding RNA genes and mediates degradation of the produced transcript by the nuclear exosome. The NNS complex also represses some stress response genes, by stimulating premature termination. A well-characterized stress response in yeast is flocculation, where cells aggregate to form flocs under expression of lectin-encoding genes designated as FLOs. In this study, we demonstrated the role of the NNS complex and Rrp6p in the expression of flocculation genes: FLO1, FLO5, FLO9, and FLO10. Furthermore, a deletion mutant of the RNA processing machinery (RNT1), and SEN1 mutants that are unable to interact with Rnt1p, exhibit a flocculation phenotype. In summary, we have identified a cooperative role of Rnt1p, Rrp6p and the NNS complex in the repression of FLO genes.
- Reference Type
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Journal Article |
Research Support, Non-U.S. Gov't
- Authors
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Singh V,
Azad GK,
Sariki SK,
Tomar RS
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- FLO9 | NRD1 | FLO1 | FLO5 | FLO10 | RRP6 | RNT1 | NAB3 | SEN1 | NRD1 snoRNA termination complex
- FLO11
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