Reference: Bastia D and Zaman S (2014) Mechanism and physiological significance of programmed replication termination. Semin Cell Dev Biol 30:165-73

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Abstract


Replication forks in both prokaryotic and eukaryotic systems pause at random sites due to depletion of dNTP pools, DNA damage, tight binding nonhistone proteins or unusual DNA sequences and/or structures, in a mostly non-polar fashion. However, there is also physiologically programmed replication termination at sequence-specific authentic replication termini. Here, the structure and functions of programmed replication termini, their mechanism of action and their diverse physiological functions in prokaryotes and eukaryotes have been reviewed.

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Journal Article | Research Support, N.I.H., Extramural | Review
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Bastia D, Zaman S
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