Sivaram MV, et al. (2006)

Abstract

The exocyst is a conserved protein complex essential for trafficking secretory vesicles to the plasma membrane. The structure of the C-terminal domain of the exocyst subunit Sec6p reveals multiple helical bundles, which are structurally and topologically similar to Exo70p and the C-terminal domains of Exo84p and Sec15, despite <10% sequence identity. The helical bundles appear to be evolutionarily related molecular scaffolds that have diverged to create functionally distinct exocyst proteins.

PMID: 16699513
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Reference Type: Journal Article | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't
Authors: Sivaram MV, Furgason ML, Brewer DN, Munson M
Primary Lit For: SEC6 | Exocyst
Additional Lit For: EXO84 | SEC15 | EXO70
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