Moore JK (2013)

Abstract

How do cells direct the microtubule motor protein dynein to move cellular components to the right place at the right time? Recent studies in budding yeast shed light on a new mechanism for directing dynein, involving the protein She1. She1 restricts where and when dynein moves the nucleus and mitotic spindle. Experiments with purified proteins show that She1 binds to microtubules and inhibits dynein by stalling the motor on its track. Here I describe what we have learned so far about She1, based on a combination of genetic, cell biology, and biophysical approaches. These findings set the stage for further interrogation of the She1 mechanism, and raise the question of whether similar mechanisms exist in other species.

Download Citation (.nbib)

Reference Type: Journal Article | Research Support, N.I.H., Extramural
Authors: Moore JK
Primary Lit For
Additional Lit For
Review For: DYN1 | BIM1 | SHE1 | BIK1 | ARP1 | KIP2 | JNM1 | KAR9 | PAC1 | NDL1 | LDB18 | ... Show allNIP100 Show fewer

Increase the total number of rows displayed on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; to filter the table by a specific experiment type, type a keyword into the Filter box (for example, “microarray”); download this table as a .txt file using the Download button or click Analyze to further view and analyze the list of target genes using GO Term Finder, GO Slim Mapper, or SPELL.

Interaction Annotations