Silva P, et al. (2011)

Abstract

Accurate chromosome segregation relies on activity of the spindle assembly checkpoint, a surveillance mechanism that prevents premature anaphase onset until all chromosomes are properly attached to the mitotic spindle apparatus and aligned at the metaphase plate. Defects in this mechanism contribute to chromosome instability and aneuploidy, a hallmark of malignant cells. Here, we review the molecular mechanisms of activation and silencing of the spindle assembly checkpoint and its relationship to tumourigenesis.

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Reference Type: Journal Article | Research Support, Non-U.S. Gov't | Review
Authors: Silva P, Barbosa J, Nascimento AV, Faria J, Reis R, Bousbaa H
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