Wei Y and Zheng XF (2011)

Abstract

Cell growth is highly regulated and its deregulation is related to many human diseases such as cancer. Nutritional cues stimulate cell growth through modulation of TOR (target of rapamycin) signaling pathway. At the center of this pathway is a large serine/threonine protein kinase TOR, which forms two distinct functional complexes TORC1 and TORC2 in a cell. TORC1 senses the environmental nutrient quality/quantity and transmits the growth signals to multiple effectors to regulate a broad spectrum of biological processes including translation initiation, ribosome biogenesis, autophagy, nutrient uptake, and metabolism. By using budding yeast as a model, recent studies began to elucidate the complexity of the TOR signaling pathway.

PMID: 21863495
DOI full text
PubMed
PubTator

Download Citation (.nbib)

Reference Type: Journal Article | Review
Authors: Wei Y, Zheng XF
Primary Lit For: TORC2 complex
Additional Lit For: TOR1 | TOR2
Review For

Increase the total number of rows displayed on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; to filter the table by a specific experiment type, type a keyword into the Filter box (for example, “microarray”); download this table as a .txt file using the Download button or click Analyze to further view and analyze the list of target genes using GO Term Finder, GO Slim Mapper, or SPELL.

Interaction Annotations