Reference: da Silva FR, et al. (2011) Oroidin inhibits the activity of the multidrug resistance target Pdr5p from yeast plasma membranes. J Nat Prod 74(2):279-82

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Abstract


Oroidin was isolated from the marine sponge Agelassventres and inhibited the activity and function of Pdr5p, an enzyme responsible for the multidrug resistance phenotype in Saccharomyces cerevisiae. This compound may help in the development of new drugs that reverse this dangerous phenotype of pathogenic yeast and fungi.

Reference Type
Journal Article | Research Support, Non-U.S. Gov't
Authors
da Silva FR, Tessis AC, Ferreira PF, Rangel LP, Garcia-Gomes AS, Pereira FR, Berlinck RG, Muricy G, Ferreira-Pereira A
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