The positioning of chromosomal domains in the interphase nucleus is proposed to facilitate gene regulation in simple cells such as yeasts and to coordinate patterns of gene expression and activation of origins of replication during cell differentiation in complex organisms. Over the past 10-12 years, detailed information on the organization of interphase chromosomes has accumulated from three-dimensional microscopy of fixed cells labeled by in situ hybridization and immunofluorescence techniques. Recently, time-lapse fluorescence microscopy of GFP-tagged domains has shown that interphase chromatin can be highly dynamic, moving distances >0.5 microm within seconds. Novel fluorescence techniques show that most nuclear proteins are also highly mobile. Both the rapid oscillations of chromatin and long-range movements of chromosomes suggest new mechanisms for spatial and temporal control of transcription and other nuclear events.
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| Evidence ID | Analyze ID | Gene/Complex | Systematic Name/Complex Accession | Qualifier | Gene Ontology Term ID | Gene Ontology Term | Aspect | Annotation Extension | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Phenotype | Experiment Type | Experiment Type Category | Mutant Information | Strain Background | Chemical | Details | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Disease Ontology Term | Disease Ontology Term ID | Qualifier | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Regulator | Regulator Systematic Name | Target | Target Systematic Name | Direction | Regulation of | Happens During | Regulator Type | Direction | Regulation Of | Happens During | Method | Evidence | Strain Background | Reference |
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| Site | Modification | Modifier | Source | Reference |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Allele | Assay | Annotation | Action | Phenotype | SGA score | P-value | Source | Reference | Note |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Assay | Annotation | Action | Modification | Source | Reference | Note |
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| Complement ID | Locus ID | Gene | Species | Gene ID | Strain background | Direction | Details | Source | Reference |
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| Evidence ID | Analyze ID | Dataset | Description | Keywords | Number of Conditions | Reference |
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