Reference: Gallego-Sánchez A, et al. (2010) Control of PCNA deubiquitylation in yeast. Biochem Soc Trans 38(Pt 1):104-9

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Abstract


Eukaryotes ubiquitylate the replication factor PCNA (proliferating-cell nuclear antigen) so that it tolerates DNA damage. Although, in the last few years, the understanding of the evolutionarily conserved mechanism of ubiquitylation of PCNA, and its crucial role in DNA damage tolerance, has progressed impressively, little is known about the deubiquitylation of this sliding clamp in most organisms. In the present review, we will discuss potential molecular mechanisms regulating PCNA deubiquitylation in yeast.

Reference Type
Journal Article | Research Support, Non-U.S. Gov't | Review
Authors
Gallego-Sánchez A, Conde F, San Segundo P, Bueno A
Primary Lit For
PCNA homotrimer
Review For
POL30 | UBP7 | UBP12 | DOA4 | UBP9 | UBP8 | UBP1 | UBP14 | UBP13 | UBP6 | UBP11 | ... Show all