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Reference: Röther S, et al. (2006) Swt1, a novel yeast protein, functions in transcription. J Biol Chem 281(48):36518-25

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Abstract

The conserved TREX complex couples transcription to nuclear mRNA export. Here, we report that the uncharacterized open reading frame YOR166c genetically interacts with TREX complex components and encodes a novel protein named Swt1 for "synthetically lethal with TREX." Co-immunoprecipitation experiments show that Swt1 also interacts with the TREX complex biochemically. Consistent with a potential role in transcription as suggested by its interaction with TREX, Swt1 localizes mainly to the nucleus. Importantly, deletion of Swt1 leads to decreased transcription. Taken together, these data suggest that Swt1 functions in gene expression in conjunction with the TREX complex.

Reference Type
Journal Article | Research Support, Non-U.S. Gov't
Authors
Röther S, Clausing E, Kieser A, Strässer K
Primary Lit For
RPO21 | SWT1 | THO2 | TREX complex
Additional Lit For
SUB2 | RTF1 | THP2 | DST1 | YRA1 | MFT1 | HPR1 | SPT5

Gene Ontology Annotations

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Gene/Complex Qualifier Gene Ontology Term Aspect Annotation Extension Evidence Method Source Assigned On Reference

Interaction Annotations

Genetic Interactions

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Interactor Interactor Allele Assay Annotation Action Phenotype SGA score P-value Source Reference

Physical Interactions

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Interactor Interactor Assay Annotation Action Modification Source Reference