A change from mutant to normal phenotype of a genetic trait is often\ndue to a mutation at a second locus which suppresses the mutant\nphenotype. Although it may be the consequence of limited testing, the\ngeneral observation is that suppressor genes are restricted in their\naction to restoring to normal or nearnormal the character associated\nwith the mutant alleles of a single locus or even a specific allele at\nthe locus (YANOFSKY 1960). However, there are now known several cases\nwhere the effects of genes at two or more loci are suppressed by a\nsingle suppressor gene. Three examples of multiple suppression are:\n1) sue-Hw in Drosophila which suppresses, in addition to "Hairy wing,"\nthe diverse morphological traits controlled by seven different loci\n(E. B. LEWIS unpublished, cited by WAGNER and MITCHELL 1955),\n2) su-pyr in Neurospora which suppresses a pyrimidine and two different\nproline mutants (MITCHELL and MITCHELL 1952; and 3) several\nsuppressors in Escherichia coli which restore galactose fermentation,\ncysteine independence, and susceptibility to bacteriophage (CAMPBELL\n1961).\n In the yeast Sacharomyces cerevisiae, the genetic analysis of\ntetrads for the segregation of twenty or more genes in the same cross\nprovides circumstances favorable for the detection of suppressors\nwhich affect more than one character. Three cases of such\n"super-suppressors" are described below.
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| Evidence ID | Analyze ID | Gene/Complex | Systematic Name/Complex Accession | Qualifier | Gene Ontology Term ID | Gene Ontology Term | Aspect | Annotation Extension | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Phenotype | Experiment Type | Experiment Type Category | Mutant Information | Strain Background | Chemical | Details | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Disease Ontology Term | Disease Ontology Term ID | Qualifier | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Regulator | Regulator Systematic Name | Target | Target Systematic Name | Direction | Regulation of | Happens During | Regulator Type | Direction | Regulation Of | Happens During | Method | Evidence | Strain Background | Reference |
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| Site | Modification | Modifier | Source | Reference |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Allele | Assay | Annotation | Action | Phenotype | SGA score | P-value | Source | Reference | Note |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Assay | Annotation | Action | Modification | Source | Reference | Note |
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| Complement ID | Locus ID | Gene | Species | Gene ID | Strain background | Direction | Details | Source | Reference |
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| Evidence ID | Analyze ID | Dataset | Description | Keywords | Number of Conditions | Reference |
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