Conaway RC, et al. (2005)

Abstract

Mediator is an essential component of the RNA polymerase II general transcriptional machinery and plays a crucial part in the activation and repression of eukaryotic mRNA synthesis. The Saccharomyces cerevisiae Mediator was the first to be defined and is a high molecular mass complex composed of >20 distinct subunits that performs multiple activities in transcription. Recent studies have defined the subunit composition and associated activities of mammalian Mediator, and revealed a striking evolutionary conservation of Mediator structure and function from yeast to man.

PMID: 15896743
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Reference Type: Journal Article | Research Support, N.I.H., Extramural | Research Support, U.S. Gov't, P.H.S. | Review
Authors: Conaway RC, Sato S, Tomomori-Sato C, Yao T, Conaway JW
Primary Lit For: DNA-directed RNA polymerase II complex
Additional Lit For
Review For: ROX3 | SRB7 | MED6 | SIN4 | SRB4 | SRB5 | PGD1 | MED2 | SRB6 | NUT2 | CSE2 | ... Show all

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