Cotranslational targeting directly couples synthesis of proteins to their translocation across or insertion into membranes. The signal recognition particle (SRP) and its membrane-bound receptor facilitate the targeting of the translation machinery, the ribosome, via recognition of a signal sequence in the nascent peptide chain. By combining structures of free and ribosome-bound SRP we derive a structural model describing the dynamic nature of SRP when it meets the ribosome.

• PMID: 15523481
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Reference Type

Journal Article | Research Support, Non-U.S. Gov't | Review

Authors

Wild K, Halic M, Sinning I, Beckmann R

Primary Lit For

Additional Lit For

Review For

SRP54