CNA1 and CNA2 encode isoforms of the catalytic subunit of calcineurin, a Ser/Thr-specific phosphoprotein phosphatase regulated by Ca(2+)/calmodulin. The relative abundance of both transcripts was evaluated during growth of Saccharomyces cerevisiae in glucose by reverse-transcription polymerase chain reaction using PDA1 mRNA as a novel internal standard. CNA1 and CNA2 were concomitantly transcribed with different average expression ratios at the exponential and stationary growth phases and both showed a remarkable drop in the expression at diauxie. Prolonged hyper-osmotic shock resulted in a moderate induction of CNA1, whereas CNA2 expression was not affected.

• PMID: 12725927
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Reference Type

Journal Article | Research Support, Non-U.S. Gov't

Authors

Del Aguila EM, Silva JT, Paschoalin VM

Primary Lit For

CMP2 | CNA1 | Calcineurin complex variant 1 | Calcineurin complex variant 2

Additional Lit For

Review For