Reference: Jackson PK (2003) Ubiquitinating a phosphorylated Cdk inhibitor on the blades of the Cdc4 beta-propeller. Cell 112(2):142-4

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Abstract


Substrate binding by the SCFCdc4 ubiquitin ligase is regulated by phosphorylation. In this issue of Cell, Orlicky et al. describe the crystal structure of the Cdc4 subunit bound to a high-affinity substrate phosphopeptide. This structure provides insights into the binding interaction and how a precise mechanism involving multiple regulatory phosphorylations may be mediated by a single binding site.

Reference Type
Comment | Journal Article
Authors
Jackson PK
Review For
CDC4