AboutBlogDownloadExploreHelpGet Data

Reference: Mandal SS, et al. (2002) FCP1, a phosphatase specific for the heptapeptide repeat of the largest subunit of RNA polymerase II, stimulates transcription elongation. Mol Cell Biol 22(21):7543-52

Reference Help

Abstract

FCP1, a phosphatase specific for the carboxy-terminal domain of RNA polymerase II (RNAP II), was found to stimulate transcript elongation by RNAP II in vitro and in vivo. This activity is independent of and distinct from the elongation-stimulatory activity associated with transcription factor IIF (TFIIF), and the elongation effects of TFIIF and FCP1 were found to be additive. Genetic experiments resulted in the isolation of several distinct fcp1 alleles. One of these alleles was found to suppress the slow-growth phenotype associated with either the reduction of intracellular nucleotide concentrations or the inhibition of other transcription elongation factors. Importantly, this allele of fcp1 was found to be lethal when combined individually with two mutations in the second-largest subunit of RNAP II, which had been shown previously to affect transcription elongation.

Reference Type
Journal Article | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, P.H.S.
Authors
Mandal SS, Cho H, Kim S, Cabane K, Reinberg D
Primary Lit For
FCP1 | General transcription factor TFIIF complex | DNA-directed RNA polymerase II complex

Gene Ontology Annotations 1 entry for 1 gene

Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

Gene/ComplexQualifierGene Ontology TermAnnotation ExtensionEvidenceSourceAssigned On
FCP1involved inregulation of transcription by RNA polymerase IIIGI with RPB2SGD2013-08-07
Showing 1 to 1 of 1 entries