Nicholson DW and Neupert W (1989)

Abstract

The covalent attachment of heme to apocytochrome c, and therefore the import of cytochrome c into mitochondria, is dependent on both NADH plus a cytosolic cofactor that has been identified to be FMN or FAD. NADH in concert with flavin nucleotides mediates the reduction of heme. Heme in the reduced state is a prerequisite for its covalent attachment to apocytochrome c by the enzyme cytochrome c heme lyase and thus for subsequent translocation of cytochrome c across the outer mitochondrial membrane during import.

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Reference Type: Journal Article | Research Support, Non-U.S. Gov't
Authors: Nicholson DW, Neupert W
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Additional Lit For: CYC3
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