An increasing number of protein solution structures, calculated on the basis of nuclear Overhauser enhancement cross-peak intensities observed in two- or higher dimensional NOESY experiments, are becoming available. Among these structures regions of uncertainty are frequently observed particularly with respect to loops and surface side chains. These are commonly ascribed to either a lack of NOE constraints or to some intrinsic mobility within the protein. A powerful method of structural analysis which may resolve this problem is based on the information content of the chemical shift. The value of such an analysis is illustrated here with cytochromes b5 and c, proteins for which high-quality crystallographic and NMR data are available. Comparison of these using a pseudocontact shift-based analysis indicates that NOE data should be combined with the chemical shift data in order to uncover fully the ensemble of protein states and their dynamics in solution.
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| Evidence ID | Analyze ID | Gene/Complex | Systematic Name/Complex Accession | Qualifier | Gene Ontology Term ID | Gene Ontology Term | Aspect | Annotation Extension | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Phenotype | Experiment Type | Experiment Type Category | Mutant Information | Strain Background | Chemical | Details | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Disease Ontology Term | Disease Ontology Term ID | Qualifier | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Regulator | Regulator Systematic Name | Target | Target Systematic Name | Direction | Regulation of | Happens During | Regulator Type | Direction | Regulation Of | Happens During | Method | Evidence | Strain Background | Reference |
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| Site | Modification | Modifier | Source | Reference |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Allele | Assay | Annotation | Action | Phenotype | SGA score | P-value | Source | Reference | Note |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Assay | Annotation | Action | Modification | Source | Reference | Note |
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| Complement ID | Locus ID | Gene | Species | Gene ID | Strain background | Direction | Details | Source | Reference |
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| Evidence ID | Analyze ID | Dataset | Description | Keywords | Number of Conditions | Reference |
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