Monocyte yeast cell phagocytosis was studied in 164 rheumatic sera. The results showed that the phagocytic activity (PA) was low in 51 per cent of SLE-sera, in 12 per cent of other connective tissue disease (CTD)-sera, in 16 percent of RA-sera but in none of 30 sera from patients with other chronic arthritides. Low PA was associated with cryoglobulinaemia and subnormal C1q, C4 and C3 in the SLE-group and with subnormal C4 and signs of extra-articular disease in the RA-group. In the CTD-group, low PA was only found in 4 cases of SLE-like syndromes, all having evidence of vasculitis. The findings suggest that low phagocytic activity in presence of rheumatic sera may be related to clinical syndromes with circulating immune complexes and/or hypocomplementaemia, most often SLE.
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| Evidence ID | Analyze ID | Gene/Complex | Systematic Name/Complex Accession | Qualifier | Gene Ontology Term ID | Gene Ontology Term | Aspect | Annotation Extension | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Phenotype | Experiment Type | Experiment Type Category | Mutant Information | Strain Background | Chemical | Details | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Disease Ontology Term | Disease Ontology Term ID | Qualifier | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Regulator | Regulator Systematic Name | Target | Target Systematic Name | Direction | Regulation of | Happens During | Regulator Type | Direction | Regulation Of | Happens During | Method | Evidence | Strain Background | Reference |
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| Site | Modification | Modifier | Source | Reference |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Allele | Assay | Annotation | Action | Phenotype | SGA score | P-value | Source | Reference | Note |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Assay | Annotation | Action | Modification | Source | Reference | Note |
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| Complement ID | Locus ID | Gene | Species | Gene ID | Strain background | Direction | Details | Source | Reference |
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| Evidence ID | Analyze ID | Dataset | Description | Keywords | Number of Conditions | Reference |
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