Reference: Qiu J, et al. (1999)
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Abstract
Yeast exonuclease 1 (Exo1) is induced during meiosis and plays an important role in DNA homologous recombination and mismatch correction pathways. The human homolog, an 803-amino acid protein, shares 55% similarity to the yeast Exo1. In this report, we show that the enzyme functionally complements Saccharomyces cerevisiae Exo1 in recombination of direct repeat DNA fragments, UV resistance, and mutation avoidance by in vivo assays. Furthermore, the human enzyme suppresses the conditional lethality of a rad27Delta mutant, symptomatic of defective RNA primer removal. The purified recombinant enzyme not only displays 5'-3' double strand DNA exonuclease activity, but also shows an RNase H activity. This result indicates a back-up function of exonuclease 1 to flap endonuclease-1 in RNA primer removal during lagging strand DNA synthesis.
- Reference Type
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Journal Article |
Research Support, U.S. Gov't, P.H.S.
- Authors
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Qiu J,
Qian Y,
Chen V,
Guan MX,
Shen B
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- EXO1
Gene Ontology Annotations
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| Evidence ID |
Analyze ID |
Gene/Complex |
Systematic Name/Complex Accession |
Qualifier |
Gene Ontology Term ID |
Gene Ontology Term |
Aspect |
Annotation Extension |
Evidence |
Method |
Source |
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Reference |
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Gene |
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Phenotype |
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Strain Background |
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Details |
Reference |
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Disease Ontology Term |
Disease Ontology Term ID |
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Reference |
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| Evidence ID |
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Regulator |
Regulator Systematic Name |
Target |
Target Systematic Name |
Direction |
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Happens During |
Regulator Type |
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Post-translational Modifications
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Interactor |
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| Gene | Species | Gene ID | Strain background | Direction | Details | Source |
|---|
| EXO1 | Homo sapiens | HGNC:3511 | S288C | other complements yeast | Human EXO1 complements the mutator phenotype, UV sensitivity and recombination between direct repeats in the exo1 null allele. | SGD |