Reference: Miyahara K, et al. (1996) yAP-1- and yAP-2-mediated, heat shock-induced transcriptional activation of the multidrug resistance ABC transporter genes in Saccharomyces cerevisiae. Curr Genet 29(2):103-5

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Abstract


We have examined whether the stress-induced transcriptional activation of YDR1/PDR5/STS1 is mediated by yAP-1 and yAP-2. Of the stresses examined, heat shock-induced, rapid and transient PDR5 expression became very low in a yap1 yap2 double-gene disruptant, indicating that the yAP proteins mediate the response. Similar results were obtained with SNQ2, a close homologue of PDR5. A set of 5'-truncation derivatives of the PDR5 gene identified the region from -484 to -434 as being sufficient for the response. A sequence similar to the yAP-1 recognition element recently identified in the stress-responsive yeast genes was found in this region and in the 5'-flanking sequences of SNQ2.

Reference Type
Comparative Study | Journal Article | Research Support, Non-U.S. Gov't
Authors
Miyahara K, Hirata D, Miyakawa T
Primary Lit For
SNQ2 | CAD1 | YAP1 | Adapter complex AP-2
Additional Lit For
PDR5

Interaction Annotations


Genetic Interactions

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Physical Interactions 0 entries for 0 genes

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