Crossing-over between the dispersed repeated sequences found in eukaryotic genomes would generate chromosomal rearrangements. The stability of the yeast genome suggests the existence of some constraint on the ability of these sequences to interact by recombination. We have constructed strains with two alleles of the his3 gene located on different chromosomes. Gene conversion accounts for the majority of the recombination events between these genes, but about 10% of the events are crossovers that result in a reciprocal translocation. When one of the alleles is on an autonomously replicating centromere plasmid, recombination is 5- to 10-fold more frequent than when both alleles are chromosomal, suggesting that higher-order chromosome structure may play a role in restricting interchromosomal recombination. We have also used the translocation to deduce the orientation of the his3 and rRNA genes relative to their centromeres.
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| Evidence ID | Analyze ID | Gene/Complex | Systematic Name/Complex Accession | Qualifier | Gene Ontology Term ID | Gene Ontology Term | Aspect | Annotation Extension | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Phenotype | Experiment Type | Experiment Type Category | Mutant Information | Strain Background | Chemical | Details | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Disease Ontology Term | Disease Ontology Term ID | Qualifier | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Regulator | Regulator Systematic Name | Target | Target Systematic Name | Direction | Regulation of | Happens During | Regulator Type | Direction | Regulation Of | Happens During | Method | Evidence | Strain Background | Reference |
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| Site | Modification | Modifier | Source | Reference |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Allele | Assay | Annotation | Action | Phenotype | SGA score | P-value | Source | Reference | Note |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Assay | Annotation | Action | Modification | Source | Reference | Note |
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| Complement ID | Locus ID | Gene | Species | Gene ID | Strain background | Direction | Details | Source | Reference |
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| Evidence ID | Analyze ID | Dataset | Description | Keywords | Number of Conditions | Reference |
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