Two Saccharomyces cerevisiae genes were isolated based upon their dosage-dependent rescue of a temperature-sensitive mutation of the gene CDC28, which encodes a protein kinase involved in control of cell division. CLN1 and CLN2 encode closely related proteins that also share homology with cyclins. Cyclins, characterized by a dramatic periodicity of abundance through the cell cycle, are thought to be involved in mitotic induction in animal cells. A dominant mutation in the CLN2 gene, CLN2-1, advances the G1- to S-phase transition in cycling cells and impairs the ability of cells to arrest in G1 phase in response to external signals, suggesting that the encoded protein is involved in G1 control of the cell cycle in Saccharomyces.
Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.
| Gene/Complex | Qualifier | Gene Ontology Term | Annotation Extension | Evidence | Source | Assigned On |
|---|---|---|---|---|---|---|
| CLN1-CDC28 kinase complex | involved in | regulation of cell cycle G1/S phase transition | BSR | ComplexPortal | 2016-03-31 | |
| CLN3-CDC28 kinase complex | involved in | regulation of cell cycle G1/S phase transition | BSR | ComplexPortal | 2016-03-31 | |
| CLN2-CDC28 kinase complex | involved in | regulation of cell cycle G1/S phase transition | BSR | ComplexPortal | 2016-04-11 | |
| CLN2 | involved in | traversing start control point of mitotic cell cycle | IMP | SGD | 2017-06-09 |
Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.
| Gene | Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details |
|---|---|---|---|---|---|---|
| CLN2 | cell cycle progression in G1 phase: decreased duration | classical genetics | activation Allele: CLN2-1 C-terminal truncation | Other | ||
| CLN2 | cell cycle progression: abnormal | classical genetics | activation Allele: CLN2-1 C-terminal truncation | Other | Media: nitrogen starvation Details: arrest asynchronously rather than arresting in G1 phase when nitrogen starved | |
| CLN2 | cell cycle progression: abnormal | classical genetics | activation Allele: CLN2-1 C-terminal truncation | Other | Details: fail to arrest as unbudded cells in the G1 phase upon entry into stationary phase | |
| CLN2 | critical cell size at START (G1 cell-size checkpoint): decreased | classical genetics | activation Allele: CLN2-1 C-terminal truncation | Other | ||
| CLN2 | pheromone-induced cell cycle arrest: decreased | classical genetics | activation Allele: CLN2-1 C-terminal truncation | Other | Details: requires 3-fold higher concentration of alpha factor for cell cycle arrest | |
| CLN2 | viable | classical genetics | null Allele: cln2-Δ | Other | ||
| CLN1 | viable | classical genetics | null Allele: cln1-Δ | Other |