The c-Myc and E2F transcription factors are among the most potent regulators of cell cycle progression in higher eukaryotes. This report describes the isolation of a novel, highly conserved 434 kDa protein, designated TRRAP, which interacts specifically with the c-Myc N terminus and has homology to the ATM/PI3-kinase family. TRRAP also interacts specifically with the E2F-1 transactivation domain. Expression of transdominant mutants of the TRRAP protein or antisense RNA blocks c-Myc- and E1A-mediated oncogenic transformation. These data suggest that TRRAP is an essential cofactor for both the c-Myc and E1A/E2F oncogenic transcription factor pathways.

• PMID: 9708738
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Reference Type

Journal Article | Research Support, U.S. Gov't, P.H.S.

Authors

McMahon SB, Van Buskirk HA, Dugan KA, Copeland TD, Cole MD

Primary Lit For

Additional Lit For

TRA1

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