Reference: Hirshberg M, et al. (1997) The crystal structure of human rac1, a member of the rho-family complexed with a GTP analogue. Nat Struct Biol 4(2):147-52

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Abstract


The crystal structure of human rac1, a member of the rho family of small G-proteins, complexed with the non-hydrolysable GTP analogue, guanosine-5'-(beta gamma-imino)triphosphate (GMPPNP), has been determined by X-ray analysis at a resolution of 1.38 A. Comparison with the structure of H-ras indicates that rac1 has an extra alpha-helical domain that is characteristic of the rho G proteins, and may be involved in the signalling pathway of this family.

Reference Type
Comparative Study | Journal Article | Research Support, Non-U.S. Gov't
Authors
Hirshberg M, Stockley RW, Dodson G, Webb MR
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