Reference: Burgess SM and Guthrie C (1993) Beat the clock: paradigms for NTPases in the maintenance of biological fidelity. Trends Biochem Sci 18(10):381-4

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Abstract


Kinetic proofreading is a strategy used by cells to reduce the number of errors made when replicating and expressing genetic information. Recent advances in mRNA splicing suggest a variation on the theme of previously described kinetic proofreading mechanisms, which may apply to other multicomponent assembly processes in the cell.

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Journal Article | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, P.H.S. | Review
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Burgess SM, Guthrie C
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