The interaction of concanavalin A with alpha-mannans from several species of microorganisms has been studied by the techniques of quantitative precipitation and hapten inhibition. Similar to concanavalin A-dextran precipitation, the reaction between concanavalin A and yeast mannan (Saccharomyces cerevisiae) is optimal near neutrality (pH 5.7 to 6.7). Among the polysaccharides which form a precipitate with concanavalin A, i.e. glycogens, amylopectins, mannans, dextrans, and levans, mannans appear to be the most reactive. This is illustrated by hapten inhibition studies conducted on the concanavalin A-mannan system wherein relatively larger amounts of inhibitors are required to effect the same percentage inhibition as concanavalin A-dextran or concanavalin A-levan precipitation. The inhibition of a number of mannose-containing oligosaccharides has been examined, and data are presented which suggest that the concanavalin A-combining sites may be more extensive than hitherto believed, and may, in fact, be complementary to a sequence of several alpha-(1 -> 2)-D-mannopyranosyl residues.
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| Evidence ID | Analyze ID | Gene/Complex | Systematic Name/Complex Accession | Qualifier | Gene Ontology Term ID | Gene Ontology Term | Aspect | Annotation Extension | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Phenotype | Experiment Type | Experiment Type Category | Mutant Information | Strain Background | Chemical | Details | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Disease Ontology Term | Disease Ontology Term ID | Qualifier | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Regulator | Regulator Systematic Name | Target | Target Systematic Name | Direction | Regulation of | Happens During | Regulator Type | Direction | Regulation Of | Happens During | Method | Evidence | Strain Background | Reference |
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| Site | Modification | Modifier | Source | Reference |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Allele | Assay | Annotation | Action | Phenotype | SGA score | P-value | Source | Reference | Note |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Assay | Annotation | Action | Modification | Source | Reference | Note |
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| Complement ID | Locus ID | Gene | Species | Gene ID | Strain background | Direction | Details | Source | Reference |
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| Evidence ID | Analyze ID | Dataset | Description | Keywords | Number of Conditions | Reference |
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