Aerobic yeast mitochondria contain a unique isozyme of acetaldehyde dehydrogenase that accounts for the ability of yeast mitochondria to respire with acetaldehyde as a substrate. Mitochondrial acetaldehyde dehydrogenase has a high affinity for acetaldehyde, is active with NAD+ and NADP+, is stimulated by K+, and appears to be the same acetaldehyde dehydrogenase previously isolated from yeast autolysates by Black ((1951) Arch. Biochem. Biophys. 34, 86-97) and Jakoby and coworkers (Steinman, C. R. and Jakoby, W. B. (1967) J. Biol. Chem. 242, 5019-5023; Steinman, C. R. and Jakoby, W. B. (1968) J. Biol. Chem. 243,730-734; Clark, J. F. and Jakoby, W. B. (1970) J. Biol. Chem. 245, 6065-6071; Clark, J. F. and Jakoby, W. B. (1970) J. Biol. Chem. 245, 6072-6077; Bradbury, S. L. and Jakoby, W. B. (1971) J. Biol. Chem. 246, 1834-1840; Bradbury, S. L. and Jakoby, W. B. (1972) Proc. Natl. Acad. Sci. U.S. 69, 2373-2376). The enzyme is inhibited by Li+, Mg2+, and Disulfiram. Mitochondrial acetaldehyde dehydrogenase appears to play a role in the oxidative metabolism of ethanol, especially when yeast cells are utilizing ethanol as a source of carbon and energy for growth. The enzyme is more than 99% repressed during the growth of yeast on glucose. Yeast cells also contain a cytosol isozyme of acetaldehyde dehydrogenase that is active with NADP+, is stimulated by Mg2+, and is only partly repressed during growth on glucose. The cytosol isozyme resembles the acetaldehyde dehydrogenase previously prepared from yeast autolysates by Seegmiller ((1953) J. Biol. Chem. 201, 629-637).
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| Evidence ID | Analyze ID | Gene/Complex | Systematic Name/Complex Accession | Qualifier | Gene Ontology Term ID | Gene Ontology Term | Aspect | Annotation Extension | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Phenotype | Experiment Type | Experiment Type Category | Mutant Information | Strain Background | Chemical | Details | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Disease Ontology Term | Disease Ontology Term ID | Qualifier | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Regulator | Regulator Systematic Name | Target | Target Systematic Name | Direction | Regulation of | Happens During | Regulator Type | Direction | Regulation Of | Happens During | Method | Evidence | Strain Background | Reference |
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| Site | Modification | Modifier | Source | Reference |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Allele | Assay | Annotation | Action | Phenotype | SGA score | P-value | Source | Reference | Note |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Assay | Annotation | Action | Modification | Source | Reference | Note |
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| Complement ID | Locus ID | Gene | Species | Gene ID | Strain background | Direction | Details | Source | Reference |
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| Evidence ID | Analyze ID | Dataset | Description | Keywords | Number of Conditions | Reference |
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