Reference: Maurer RA (1988) Isolation of a yeast protein kinase gene by screening with a mammalian protein kinase cDNA. DNA 7(7):469-74

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Abstract


The gene for a new Saccharomyces cerevisiae protein kinase was identified and isolated by hybridization to a cloned cDNA for the catalytic subunit of bovine cAMP-dependent protein kinase. This newly isolated yeast gene encodes a 680-amino-acid protein that shows strong sequence similarity to several serine/threonine protein kinases. The protein kinase catalytic domain is located at the carboxy-terminal portion of the protein. A large, amino-terminal domain shows no sequence similarity to any known protein kinase. It seems likely that the amino-terminal domain mediates the effects of an unknown regulator of the newly identified yeast protein kinase.

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Journal Article | Research Support, U.S. Gov't, P.H.S.
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Maurer RA
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